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Observe Intently (one)phenobarbital will minimize the extent or outcome of fentanyl transmucosal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Watch Intently. Coadministration of fentanyl with CYP3A4 inducers may lead into a lessen in fentanyl plasma concentrations, deficiency of efficacy or, quite possibly, enhancement o